News
New Paper in Chemistry
08.06.2023
A paper on Sebastians work just came out in Chemistry. Congratulations!
We describe the development of a synthetic strategy to rapidly assembly N-acetylcysteamine (SNAC) thioesters, which are frequently used as substrate surrogates in biosynthesis studies. The strategy bases on cascades of hydroboration and Suzuki-Miyaura reaction with SNAC thioesteracrylates carried out in one-pot. Our report ist the first about a transition metal-catalysed coupling reaction in the presence of SNAC thioesters. These have previously been identified to be particularly problematic due to the sensitivity and dense functionalisation of this functional group.
Find the paper under the following link (open access):
https://www.mdpi.com/2624-8549/5/2/96