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Organische Chemie – Arbeitsgruppe Professor Dr. Frank Hahn

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New Publication in RSC Advances

07.06.2020

Part of Lisa's PhD work was published as part of the Emerging Investigators Series in RSC Advances.

In this proof-of-principle-study we show the first example of a polyketide synthase (PKS) domain immobilisation in form of a cross-linked enzyme aggregate (CLEA). In doing so, we obtained an improved biocatalyst that recovered most of its enzymatic activity, but could be repetitively re-used in semipreparative-scale reactions. Such a cross-linking strategy might be generally helpful to improve the value of PKS enzymes for chemoenzymatic synthesis as these commonly suffer from low stability and activity.

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https://pubs.rsc.org/en/Content/ArticleLanding/2021/RA/D1RA03692K

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