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Faculty of Biology, Chemistry & Earth Sciences

Organic Chemistry Prof. Dr. Frank Hahn

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Paper Published in Organic & Biomolecular Chemistry


Another part of Lisa Wagners PhD work was just published in Organic & Biomolecular Chemistry.

We have a long-standing interest on cyclase enyzmes that catalyse intramolecular oxa-Michael addition (IMOMA). This enzymatic transformation leads to chiral heterocycles that are important building blocks of many natural products and drugs.

In this paper we investigate the substrate-dependent performance of the cyclase PedPS7 from pederin biosynthesis. We reveal that this enzyme is broad-specific and provides selective access to specific cis- and trans-configured tetrahydropyrans. Remarkably, it shows a complementary selectivity pattern to AmbDH3, a member from another subgroup of the IMOMA cyclases that we have previously studied extensively.

Congratulations to Lisa!

Access the paper via this link.

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