Druckansicht der Internetadresse:

Faculty of Biology, Chemistry & Earth Sciences

Organic Chemistry Prof. Dr. Frank Hahn

Print page



New Publication in RSC Advances


Part of Lisa's PhD work was published as part of the Emerging Investigators Series in RSC Advances.

In this proof-of-principle-study we show the first example of a polyketide synthase (PKS) domain immobilisation in form of a cross-linked enzyme aggregate (CLEA). In doing so, we obtained an improved biocatalyst that recovered most of its enzymatic activity, but could be repetitively re-used in semipreparative-scale reactions. Such a cross-linking strategy might be generally helpful to improve the value of PKS enzymes for chemoenzymatic synthesis as these commonly suffer from low stability and activity.



Facebook Twitter Youtube-Kanal Instagram UBT-A Contact