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Faculty of Biology, Chemistry & Earth Sciences

Organic Chemistry Prof. Dr. Frank Hahn

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Publication in Organic Letters

17.06.2020

Our most recent publication in Organic Letters just went online.

Johannes figured out a new way to rapidly assemble biomimetic β-ketopolyene thioesters. These compounds are valuable surrogates for biosynthetic studies, but unfortunately also highly sensitive and problematic in their handling. Key was the use of a one-pot reductive Horner-Wadsworth-Emmons olefination for mild and step-economic backbone elongation and functionalisation. We additionally used the compounds produced for a biochemical study on the stereoselectivity of ketoreductase domains from giant multimodular polyketide synthases.

Find the paper at:

https://pubs.acs.org/doi/10.1021/acs.orglett.0c01348

Congratulations to Johannes, Theresa and Marius!

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