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Faculty of Biology, Chemistry & Earth Sciences

Organic Chemistry Prof. Dr. Frank Hahn

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New Publication in ACS Catalysis

30.03.2020

New work from the Hahn group was published in ACS Catalysis.

This detailed study uncovers the significant biocatalytic potential of the cyclase AmbDH3. This was among the first known enzymes, which form oxygen heterocycles with multiple stereocentres via intramolecular oxa-Michael addition. In our contribution we show that AmbDH3 exhibits a synthetically attractive combination of high stereoselectivity and relaxed substrate specificity. Preparative scale conversions and chemoenzymatic natural product synthesis are also reported. Our study opens up the prospect of establishing this and similar enzymes as a novel group of biocatalysts for the synthesis of valuable oxygen heterocycles.

Find the paper at:

https://pubs.acs.org/doi/10.1021/acscatal.9b05071

And a press release of our University:

https://www.uni-bayreuth.de/de/universitaet/presse/pressemitteilungen/2020/079-neuer-biokatalysator/index.html

Congratulations, particularly to Tim, Gesche and Lisa, and thanks to Kwang-Hoon for the fruitful long-term collaboration.

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